Optimized absorption of boswellic acids
This year Indena introduced Casparome to Vitafoods, a highly standardized extract of Boswellia serrata, formulated with the Indena proprietary Phytosome technology.
The gum resin of Boswellia serrata is a treasure of traditional Indian medicine, Ayurveda, the first system of medicine to appear in the world. More than 200 compounds have been identified in resins from Boswellia serrata, but Boswellic acids have long been considered its main bioactive components, and many pre-clinical studies have confirmed their bioactivities. In particular, recent mechanistic studies have validated the capacity of the β-boswellic acid family to modulate physiological response to various challenges, but preliminary pharmacokinetic studies in animals and humans have highlighted the poor oral absorption of boswellic acids.
Indena has formulated Casperome, a purified mixture of boswellic acids from Boswellia serrata with lecithin, taking advantage of its proprietary Phytosome technology platform to optimize their absorption. In a previous pre-clinical work such superior absorption has been demonstrated both at the plasma and at the tissue level.
The randomized, double blind, cross-over comparative pharmacokinetic study in healthy volunteers with a single oral dosage of 500 mg of Casperome confirmed a marked increase of major boswellic acids in comparison with the unformulated extract. Plasma levels of most relevant boswellic acids measured after Casperome administration, in particular β-boswellic acids, were in the range of expected biological activity, thus representing a strong support for a rational dosage regimen in clinical testing. Clinical investigations in four controlled studies have given further support to the relevance of this pharmacokinetic study.